AB0515 MICRONUTRIENT DEFICIENCIES IN PATIENTS WITH SPONDYLOARTHRITIS: AGE AND GENDER IMPLICATIONS

Background: Micronutrient deficiencies (MNDs) are common among patients with chronic inflammatory diseases. These associated a pro-inflammatory status and co-morbidities, influenced by several factors, such as age gender. Objectives: No any study has investigated MNDs their correlation gender in Spondyloarthritis (SpA). With this purpose, analyzed the occurrence of anemia ferritin (Fe), vitamin D [25(OH)D], B12 (B12), folic acid (FA) cohort SpA. Methods: Levels Hb, Fe, 25(OH)D, B12, FA, were evaluated 220 SpA outpatients (137 females 83 age-matched males) Psoriatic arthritis (PsA, n=110) (n=110). Disease activity was assessed DAPSA or ASDAS-CRP appropriate functional HAQ score. Body Mass Index (BMI) selected metabolic clinic parameter. Results: Male female similar for disease duration severity well distribution diagnosis treatments (Table 1). In males, BMI higher than (P=0.03) positively correlated (P=0.01). patients, directly (P=0.03). The prevalence (Hb<12) 13.6% cohort; half anemic had PsA, others enteropathic (ESpA). Anemia resulted almost wholly (99%). male group, Hb inversely related to (P=0.01) CRP levels (P=0.008). Ferritin lower males (P=0.0003). 25(OH)D deficiency (≤20 ng/ml) present 23.2% cohort: (P=0.02). Among (P<0.001) Low serum (≤200 pmol/l) rare (13.2%), while FA (≤4 frequent (22%) defect 31% cases, females. A ESpA occurred 55% cases 62.5% defect, without difference. Mean ferritin, did not differ significantly between PsA patients. Table 1. Data from population. Females (n=137 ) Males (n=83 P Age (yrs; § 51.65 ± 13 52.9 12.8 NS (* 24 [17.2 - 50.2] 25.8 [19.6 43.6] < 0.05 (mg/l; * 2.9 [0 53] 2 61] (g/dl; 1.2 14.4 1.4 Fe 37 [2 148] 64 [4 452] (ng/ml; 28.2 [5 67] 25 50] Vitamin (pmol/l; 350 [60 990] 313 [47 797] Folic Acid 7 [1.7 40] 6.9 [1.8 39] (N/% 73/68.23 34/31.77 64/41 49/59 Concomitant IBD (n/% 56/65.9 29/34.1 (months; 69 [6 540] 76.5 [3 768] D.A. 62/45.25 47/56.6 Moderate-high 75/54.75 36/43.4 COXIB-inhibitors 21/15.4 8/9.6 cDMARDs monotherapy 35/25.5 10/12 bDMARDs 81/59.12 65/78.4 BMI, body mass index; CRP, C-reactive protein; haemoglobin; ferritin; D; psoriatic arthritis; SpA, spondyloarthritis; IBD, bowel disease; D.A., activity; cDMARDs, conventional Modifying Antirheumatic Drugs; bDMARDs, biological DMARDs; mean SD; median [min-max]. Conclusion: Our describes first time possibility relevant Furthermore, we show that could be also difference age. Of note, our findings highlight importance screening focused on This key optimizing management which inflammatory-dependent dysmetabolism is frequent. References: [1]Yamamoto EA, Jørgensen TN. Relationships Between D, Gut Microbiome, Systemic Autoimmunity. Front Immunol. 2020;10:3141. [2]Charoenngam N, Holick MF. Immunologic Effects Human Health Disease. Nutrients. 2020;12:2097. [3]Bañuls-Mirete M, Ogdie A, Guma M. Micronutrients: Essential Treatment Inflammatory Arthritis? Curr Rheumatol Rep. 2020;22:87. Disclosure Interests: None declared.